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Data comparing the pharmacokinetics of AFSTYLA and octocog alfa in patients with severe haemophilia A were recently published in The World Federation of Hemophilia’s journal Haemophilia . About AFSTYLA AFSTYLA (rVIII-SingleChain) for haemophilia A is CSL Behring’s recombinant single-chain factor VIII specifically designed for greater molecular stability and longer duration of action. AFSTYLA uses a covalent bond to form one structural entity, a single polypeptide-chain, to improve the stability of factor VIII and provide factor VIII activity with the option of twice weekly dosing. The single-chain Factor VIII molecule of AFSTYLA was originated by SK Chemicals Co. Ltd., a bio-pharmaceutical company in Korea, and licensed to CSL Behring in 2009. Read More Safety and Tolerability of AFSTYLA AFSTYLA was demonstrated to be well tolerated with no patients discontinuing the study due to adverse events. Hypersensitivity, dizziness, paraesthesia, rash, pyrexia and injection site reactions were the most common adverse events reported. One event of hypersensitivity was reported but the patient continued in the study. No inhibitors have been observed in previously treated patients. CSL Behring is currently conducting an extension study that includes previously untreated patients (PUPs), to determine the safety, efficacy and incidence of inhibitors in this high risk population. AFSTYLA is contraindicated in patients who have had life-threatening hypersensitivity reactions, including anaphylaxis to AFSTYLA, any of its components, or hamster proteins.
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